A Case Study: SynDevRx & 3DforScience
Visualizing Metabolic-Linked Cancer Treatment with Precision Animation
SynDevRx is committed to tackling the rising global challenge of cancers linked to metabolic dysfunction. To communicate this critical focus, SynDevRx partnered with 3DforScience to develop a clear and impactful 3D medical animation that illustrates how their novel therapy, evexomostat, works synergistically with PI3K inhibitors to combat tumor growth while managing harmful glucose spikes.
The Vision:
Making Complex Metabolic Oncology Understandable
Mutations in the PI3K pathway are common in many cancers and drive uncontrolled tumor growth, angiogenesis, and metastasis. However, targeting this pathway often disrupts insulin signaling in healthy cells, worsening metabolic imbalance.
SynDevRx aimed to show how evexomostat could break this vicious cycle by both enhancing anti-tumor activity and stabilizing glucose metabolism. Our task was to translate this sophisticated dual-action mechanism into an animation that resonates with oncologists, researchers, and investors alike.
+500,000
New cancer cases annually are associated with metabolic dysfunction.
80%
Of tumors show PI3K pathway mutations, highlighting the need for combination approaches.
70%
Retention increase when scientific mechanisms are explained visually through 3D animation.
A Tailored Message for Oncology Stakeholders
Our animation guides viewers through a patient’s metabolic and cellular environment—starting with insulin release and normal glucose metabolism, progressing to PI3K pathway mutation-driven cancer progression, and demonstrating how standard PI3K inhibitors can inadvertently create insulin resistance.
It then introduces evexomostat as an innovative solution: blocking cell cycle progression, sensitizing insulin pathways, and ultimately shrinking tumors while stabilizing blood sugar.
A Tailored Message for Oncology Stakeholders
Our animation guides viewers through a patient’s metabolic and cellular environment—starting with insulin release and normal glucose metabolism, progressing to PI3K pathway mutation-driven cancer progression, and demonstrating how standard PI3K inhibitors can inadvertently create insulin resistance.
It then introduces evexomostat as an innovative solution: blocking cell cycle progression, sensitizing insulin pathways, and ultimately shrinking tumors while stabilizing blood sugar.
KNOW-HOW: Scientific Rigor in Every Frame
Working alongside SynDevRx’s research team, our animators recreated the PI3K/AKT pathway, hotspot mutations, angiogenesis, and metastasis with molecular accuracy.
Dynamic transitions illustrated drug binding, insulin spikes, and the metabolic stabilization offered by evexomostat, ensuring each detail aligned with current research and the Amelia-1 study’s goals.
From concept to visualization
We began with SynDevRx’s scientific data and therapeutic narrative, storyboarding each molecular interaction step-by-step. High-resolution models and carefully choreographed camera paths brought the tumor microenvironment, insulin dynamics, and drug mechanisms to life—making the science tangible and memorable.
Solutions applied
Hand-made conceptual styling
Modelling of illustrations and designs
3D scientific animations and recreation
Our Approach to Creating an Impactful Experience
Rather than a generic overview, this animation immerses viewers in a cause-and-effect journey, highlighting why metabolic dysfunction is a stubborn obstacle in cancer treatment and how evexomostat offers a breakthrough solution.
The final visual story serves as a compelling tool for investor communications, scientific presentations, and educational outreach.
Our Approach to Creating an Impactful Experience
Rather than a generic overview, this animation immerses viewers in a cause-and-effect journey, highlighting why metabolic dysfunction is a stubborn obstacle in cancer treatment and how evexomostat offers a breakthrough solution.
The final visual story serves as a compelling tool for investor communications, scientific presentations, and educational outreach.
Our workflow:
From concept to delivery
Through iterative reviews with SynDevRx’s scientific leads, every visual element was refined for accuracy and clarity. Our integrated production process—storyboarding, modeling, animation, voiceover, and final rendering—delivered a polished asset that supports SynDevRx’s positioning as an innovator in metabolic oncology
The final outcome
The animation is now a core communication piece for SynDevRx’s Amelia-1 study, helping clarify their strategy to stakeholders worldwide. By showing how evexomostat could transform the treatment landscape for patients with metabolically driven cancers, the project reinforces SynDevRx’s commitment to better outcomes and breakthrough science.
“SynDevRx trusted us to transform their complex metabolic oncology approach into a visual narrative that educates and inspires. This animation makes clear how tackling metabolic dysfunction is key to unlocking more effective cancer therapies.”
Syndev
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