B2B is an EU-funded project that aims to develop a breakthrough technology that for the first time dissects the steps of spontaneous breast cancer metastasis to the bone and captures the 3D complexity of the process. The project started in July 2018, will run for 4 years and involves 8 partners from all over Europe.
From 3DforScience, we produced a scientific 3D animation that explains how the B2B device works to study breast cancer metastasis in the bone. Breast cancer hits 1 woman in 8, and its most common metastatic site is the bone (70%). A major hurdle to overcome breast cancer mortality is the lack of understanding of dynamics leading to the spread of breast cancer cells to the bone.
In search of a solution to this problem, and to be able to help all women who go through this disease, this project called B2B device has been created. It consists of a unique device that includes a 3D patient-derived primary lesion growing within its own self-assembled micro-vascular capillary network connected to a functional bioprinted macro-vascular tree.
The circulatory system mimics the features of human blood vessels feeding and connecting living-tumor cells from breast cancer to the target metastatic tissue: the bone, represented by a marrow-containing ossicle. To shed light on the bone metastatic process, B2B aims to develop a breakthrough technology that for the first time dissects the steps of spontaneous breast cancer metastasis to the bone and captures the 3D complexity of the process.
The B2B device includes macro-size organoids from breast tumor and bone, assembled with a macro-to-micro vascular network. This level of physiological complexity is required to capture the key elements of the metastatic process. For the dissemination of this great project, a better understanding of this medical device and to provide value, we developed this 3D animation video thanks to our team of scientists, animators and creatives. It was possible to explain in a simple way what this device is designed for, as well as the behavior of cancer cells and the factors that favor or hinder their migration.
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